Based on the materials of a series of expeditions carried out by Marine Hydrophysical Institute (Sevastopol) and Southern Scientific Research Institute of Marine Fisheries and Oceanography (Kerch) during 2002-2013, a regression equation was obtained indicating the presence of a fairly close inverse correlation relationship between salinity and the concentration of colored dissolved organic matter in the open waters of the Sea of Azov. It is shown that the closeness of the correlation dependence between these values depends significantly on the presence of dissolved organic matter of anthropogenic origin in the waters of the studied region. Using this equation, according to the known average monthly salinity fields, the concentration fields of colored dissolved organic matter were calculated and the regularities of their structure and intra-annual variability were analyzed. It is found that the field of the studied matter is characterized by low concentration and relative homogeneity. In the open water area of the sea, salinity variations determined by the intra-annual variation in the runoff volume of the Don and Kuban Rivers do not significantly affect the spatiotemporal variability in the field of colored dissolved organic matter. It is shown that a close inverse correlation between the content of colored dissolved organic matter and salinity is an indicator of the good quality of water. A weak or positive correlation between these quantities is a sign of the presence of dissolved organic substances of anthropogenic nature in the aquatic environment.